Sweet Syndrome

Diagnostic criteria for Sweet syndrome (acute febrile neutrophilic dermatosis).

Major Criteria

Abrupt onset of painful erythematous plaques or nodules
Histopathologic evidence of dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis

Minor Criteria

Pyrexia >38°C
Association with underlying hematologic or visceral malignancy, inflammatory disease or pregnancy, or preceded by an upper respiratory or gastrointestinal infection or vaccination
Excellent response to systemic corticosteroids or potassium iodide
Abnormal laboratory values at presentation (3 of 4): 1) Erythrocyte sedimentation rate >20 mm/hr, 2) Positive C-reactive protein test result 3) >8,000 leukocytes/mm3 4) >70% neutrophils/mm3

Source: Adapted from Walker DC, Cohen PR: Trimethoprim-sulfamethoxazoleassociated acute febrile neutrophilic dermatosis: case report and review of drug induced Sweet’s syndrome. J Am Acad Dermatol 34:918–923, 1996

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