Rheumatology & Immunology · criteria

Hypersensitivity Vasculitis

American College of Rheumatology 1990 classification criteria for hypersensitivity vasculitis (≥3 of 5 criteria: sensitivity 71.0%, specificity 83.9%).

Criteria (≥3 of 5 for classification)

Age at onset >16 yr • Development of symptoms after 16 yr of age
Medication at disease onset • Medication that may have been a precipitating factor was taken at the onset of symptoms
Palpable purpura • Slightly elevated purpuric rash over 1 or more areas; does not blanch with pressure and is not related to thrombocytopenia
Maculopapular rash • Flat and raised lesions of various sizes over 1 or more areas of the skin
Biopsy, including arteriole and venule • Histologic changes showing granulocytes in a perivascular or extravascular location

Source: Adapted from Calabrese LH, Michel BA, Bloch DA, et al: The American College of Rheumatology 1990 criteria for the classification of hypersensitivity vasculitis, Arthritis Rheum 33:1108–1113, 1990 (Table 2, p 1110); and Textbook of pediatric rheumatology, ed 7, Philadelphia, 2016, Elsevier (Table 38.2, p 511).

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