Rheumatology & Immunology · criteria

Systemic Lupus Erythematosus (ACR)

Revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus.

Criteria

Malar rash
Discoid rash
Photosensitivity
Oral or nasal ulcers
Arthritis • Nonerosive, ≥2 joints
Serositis • Pleuritis, pericarditis, or peritonitis
Renal manifestations • Consistent renal biopsy • Persistent proteinuria or renal casts
Seizure or psychosis
Hematologic manifestations • Hemolytic anemia • Leukopenia (<4,000 leukocytes/mm3) • Lymphopenia (<1,500 leukocytes/mm3) • Thrombocytopenia (<100,000 thrombocytes/mm3)
Immunologic abnormalities • Positive anti–double-stranded DNA or anti-Smith antibody • False-positive rapid plasma reagin test result, positive lupus anticoagulant test result, or elevated anticardiolipin IgG or IgM antibody
Positive antinuclear antibody test result

Source: Adapted from Hochberg MC: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum 40:1725, 1997.

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