Eosinophilic Pneumonia

IDIOPATHIC CHRONIC EOSINOPHILIC PNEUMONIA

• 1) Diffuse pulmonary alveolar consolidation with air bronchogram and/or ground-glass opacities at chest imaging, especially with peripheral predominance. 2) Eosinophilia at bronchoalveolar lavage differential cell count ≥ 40% (or peripheral blood eosinophils ≥ 1,000/mm3). 3) Respiratory symptoms present for at least 2 to 4 wk. 4) Absence of other known causes of eosinophilic lung disease (especially exposure to drug susceptible to induce pulmonary eosinophilia)

IDIOPATHIC ACUTE EOSINOPHILIC PNEUMONIA

• 1) Acute onset with febrile respiratory manifestations (≤1 mo, and especially ≤ 7 days duration before medical examination). 2) Bilateral diffuse infiltrates on imagingBilateral diffuse infiltrates on imaging. 3) PaO2 on room air ≤ 60 mm Hg (8 kPa), or PaO2/FIO2 ≤ 300 mm Hg (40 kPa), or oxygen saturation on room air < 90%. 4) Lung eosinophilia, with ≥ 25% eosinophils at BAL differential cell count (or eosinophilic pneumonia at lung biopsy when done). 5) Absence of determined cause of acute eosinophilic pneumonia (including infection or exposure to drugs known to induce pulmonary eosinophilia). Recent onset of tobacco smoking or exposure to inhaled dusts may be present.