Criteria

1) Impaired consciousness/coma
2) Repeated generalized convulsions
3) Renal failure (Serum Creatinine >3 mg/dl)
4) Jaundice (Serum Bilirubin >3 mg/dl)
5) Severe anaemia (Hb <5 g/dl)
6) Pulmonary oedema/acute respiratory distress syndrome
7) Hypoglycaemia (Plasma Glucose <40 mg/dl)
8) Metabolic acidosis
9) Circulatory collapse/shock (Systolic BP<80 mm Hg, <70 mm Hg in children)
10) Abnormal bleeding and DIC
11) Haemoglobinuria
12) Hyperthermia (Temperature >104o F)
13) Hyperparasitaemia (>5% parasitized RBCs in low endemic and >10% in hyperendemic areas)

Severe/Complicated Malaria