Hematology & Oncology · criteria

Polycythemia Vera

WHO 2008 diagnostic criteria for polycythemia vera (both major plus one minor, or first major plus two minor).

Major Criteria

1) Hb >18.5 g/dL (men) or Hb >16.5 g/dL (women) or Hb or Hct >99th percentile of reference range for age, sex, or altitude of residence or Hb >17 g/dL (men) or Hb >15 g/dL (women) if associated with a sustained increase of ≥2 g/dL from baseline that cannot be attributed to correction of iron deficiency or Elevated red cell mass >25% above mean normal predicted value
2) Presence of JAK2 or similar mutation

Minor Criteria

1) Bone marrow trilineage myeloproliferation
2) Subnormal serum erythropoietin level
3) Endogenous erythroid colony growth

Interpretation

Diagnosis requires both major criteria and one minor criterion, or the first major criterion and two minor criteria.

Source: Reference: From Tefferi A, Vardiman JW: Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization

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