Polycythemia Vera

Major Criteria

• 1) Hb >18.5 g/dL (men) or Hb >16.5 g/dL (women) or Hb or Hct >99th percentile of reference range for age, sex, or altitude of residence or Hb >17 g/dL (men) or Hb >15 g/dL (women) if associated with a sustained increase of ≥2 g/dL from baseline that cannot be attributed to correction of iron deficiency or Elevated red cell mass >25% above mean normal predicted value
• 2) Presence of JAK2 or similar mutation

Minor Criteria

• 1) Bone marrow trilineage myeloproliferation
• 2) Subnormal serum erythropoietin level
• 3) Endogenous erythroid colony growth

Interpretation

• Diagnosis requires both major criteria and one minor criterion, or the first major criterion and two minor criteria.