Pediatric-Onset Polyarteritis Nodosa

Criteria

• Histopathology • Necrotizing vasculitis in medium or small arteries
• Angiographic abnormalities • Angiography showing aneurysm, stenosis, or occlusion of medium or small artery not from noninflammatory cause
• Cutaneous findings • Livedo reticularis, tender subcutaneous nodules, superficial skin ulcers, deep skin ulcers, digital necrosis, nail bed infarctions, or splinter hemorrhages
• Muscle involvement • Myalgia or muscle tenderness
• Hypertension • Systolic or diastolic blood pressure >95th percentile for height
• Peripheral neuropathy • Sensory peripheral neuropathy, motor mononeuritis multiplex
• Renal involvement • Proteinuria (>300 mg/24 hr equivalent), hematuria or red blood cell casts, impaired renal function (glomerular filtration rate <50% normal)

Interpretation

• 89.6% sensitivity and 99.6% specificity for the diagnosis of childhood-onset polyarteritis nodosa