Multiple Sclerosis (McDonald Criteria)

≥2 clinical attacks

• Number of lesions with objective clinical evidence: ≥2 Additional data needed for diagnosis: None
• Number of lesions with objective clinical evidence: 1 (as well as clear-cut historical evidence of a previous attack involving a lesion in a distinct anatomic location) Additional data needed for diagnosis: None
• Number of lesions with objective clinical evidence: 1 Additional data needed for diagnosis: Dissemination in space demonstrated by an additional clinical attack implicating a different CNS site or by MRI

1 clinical attack

• Number of lesions with objective clinical evidence: ≥2 Additional data needed for diagnosis: Dissemination in time demonstrated by an additional clinical attack or by MRI OR demonstration of CSF-specific OCBs
• Number of lesions with objective clinical evidence: 1 Additional data needed for diagnosis: • Dissemination in space demonstrated by an additional clinical attack implicating a different CNS site or by MRI AND • Dissemination in time demonstrated by an additional clinical attack or by MRI OR demonstration of CSF-specific OCBs